All eyes will be on Westfield Matildas veteran Lisa De Vanna and her Fiorentina side this weekend as they play a huge Serie A match against Juventus.
The Violets are currently in third place in Italy, three points behind the league-leading Juve.
It places huge significance on this weekend’s fixture between the two clubs, which kicks off at 6.45am on Sunday (AEDT).
Fiorentina head into the clash in ominous form, having put four goals past Verona last weekend in a dominant 4-2 triumph.
If they can get another three points in this one, it will send a clear message to the rest of the Serie A they are genuine contenders for the title.
Meanwhile, Emily Gielnik and her Bayern Munich side host SGS Essen at 12am on Monday morning (AEDT), with both sides in the top four of the Bundesliga.
Gielnik’s Bayern, who drew 1-1 with league-leaders Wolfsburg last time out, are currently third and three points ahead of fourth-place Essen.
A win for Bayern could seem them leapfrog Hoffenheim into second.
In England, Jacynta Galabadaarachchi's West Ham United welcome Manchester United to The Rush Green Stadium at 2am on Monday morning (AEDT).
The Hammers lost a five-goal thriller to Reading last weekend and will need to tighten up defensively to overcome United, who are currently fifth.
While she won’t feature for her new club for another month, Sam Kerr’s Chelsea – leaders in England’s Women’s Super League, travel to Merseyside for a clash with fourth-placed Everton at 11.30pm on Sunday (AEDT).
Elsewhere, Alex Chidiac's Atletico Madrid are away at lowly Real Betis at 1.30am on Sunday (AEDT).
Chidiac has been sidelined for a number of weeks as she recovers from ankle ligament damage.
She may not be back in time for this clash but reigning champions Atletico will be keen to keep the pressure on league-leaders Barcelona, who are one point ahead at the top.