A West Coast Derby in the NWSL will see San Diego aim to keep their spot as first on the table when they take on Angel City FC; while Kansas City Current and Racing Louisville look to climb the table.
San Diego Wave FC will be looking to hold on to first place when they travel to the Banc of California Stadium in Los Angeles to take on rivals Angel City FC.
Kicking off in Louisville, Alex Chidiac's Racing Louisville will be hoping to pick up their first win in over five games when they host 10th-placed NJ/NY Gotham FC.
Racing drew 2-2 with Orlando in their last game, with Chidiac coming off the bench in the draw. Meanwhile, Gotham is still winless in over a month of action and has already lost to Racing once this season when the side from Louisville beat them 1-0.
Gotham has been unable to score in their last three games, going down to Chicago, San Diego and Kansas City and will be looking to make a statement early. Gotham has four players out on international duty, with two of these players being Midge Purce and Ifeoma Onumonu, Gotham's last two players to find the back of the net.
This game will kick off on Saturday morning at 10:00 am AEST.
Moving over to the West Coast, Emily van Egmond's San Diego will take on Angel City FC in the California Derby. Wave FC recorded a 2-1 win over the reigning champions last weekend and will be going into this game on a high, while Angel City will be aiming to end their two-game winless streak against San Diego.
Both teams will be without some key players, currently competing in the CONCACAF W Championship qualifiers. Angel City will be relying on new signing Sydney Leroux to get the hosts on the scoresheet early, making the move from Orlando Pride to Angel City throughout the month.
Van Egmond will be lining up against a number of former teammates, with Ali Riley, Leroux and Claire Emslie all playing for Angel City, with the latter officially joining the club yesterday from Everton in the WSL.
This game will kick off on Sunday at 12:30 pm AEST.
Finally, Chloe Logarzo's Kansas City Current will travel to take on Logarzo's former team in Washington Spirit, with the reigning NWSL Champions having not recorded a win since May and finding themselves sitting in ninth. Spirit will be without their top goalscorer in Ashley Hatch and also have young duo Trinity Rodman and Ashley Sanchez away on international duty.
Kansas is on a run of wins, coming into this game on a five-game unbeaten streak. Current most recently beat Houston Dash 2-1 to see them move into seventh on the table.
In good news for fans, Chloe Logarzo was a full participant in Current training and will be aiming to make her first appearance for the club since rupturing her ACL in September.
This game will kick off on Monday morning at 7:00 am AEST.